structural maintenance of chromosomes protein 6 (hSMC6, SMC6, SMC6L1)

Function: - core component of the SMC5-SMC6 complex - forms a heterodimer with SMC5 - phosphorylated - sumoylated by NSMCE2/MMS21 Structure: - flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (putative) - belongs to the SMC family, SMC6 subfamily Compartment: - nucleus - associates with chromatin Alternative splicing: named isoforms=2 Expression: - widely expressed - overexpressed in testis

Properties

SIZE: MW = 126 kD entity length = 1091 aa COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 76-83 coiled coil {226-451} coiled coil {660-914}

Database Correlations

UniProt Q96SB8 Pfam PF02463

References

UniProt :accession Q96SB8