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stromal interaction molecule 2 (STIM2, KIAA1482)
Function:
- inhibits STIM1-mediated Ca+2 influx
- oligomer with STIM1
- phosphorylated predominantly on Ser residues
Structure:
- glycosylated
- contains 1 EF-hand domain
- contains 1 SAM domain (sterile alpha motif)
Compartment: endoplasmic reticulum membrane
Expression:
- expressed in all tissues & tumor cell lines examined
General
Ca+2 binding protein
glycoprotein
membrane protein
phosphoprotein
Properties
SIZE: MW = 84 kD
entity length = 746 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-14}
EF hand
SITE: 67-102
N-glycosylation site {N135}
sterile alpha motif
NAME: sterile alpha motif
SITE: 136-204
transmembrane domain {218-235}
coiled coil {247-394}
proline-rich region
SITE: 533-559
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S680}
lysine-rich region {730-746}
MOTIF: lysine residue (SEVERAL)
Database Correlations
UniProt Q9P246
Pfam PF07647
References
UniProt :accession Q9P246