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stromal interaction molecule 1 (STIM1, GOK)
Function:
1) role in mediating Ca+2 influx following depletion of intracellular Ca+2 stores
2) acts as Ca+2 sensor in the endoplasmic reticulum (ER) via its EF-hand domain
3) upon Ca+2 depletion, translocates from the ER to the plasma membrane where it activates the Ca+2 release-activated Ca+2 (CRAC) channel subunit, TMEM142A/ORAI1.
4) forms homooligomers & heteroligomers with STIM2
Structure:
1) glycosylation is required for cell surface expression.
2) phosphorylated predominantly on Ser
3) contains 1 EF-hand domain
- contains 1 SAM domain (sterile alpha motif)
Compartment:
- cell membrane, endoplasmic reticulum membrane
- translocates from the endoplasmic reticulum to the plasma membrane in response to depletion of intracellular Ca+2
Expression: ubiquitously expressed
Pathology:
- defects in STIM1 may cause rhabdomyosarcoma & rhabdoid tumors
General
Ca+2 binding protein
glycoprotein
membrane protein
Properties
SIZE: MW = 77 kD
entity length = 685 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-22}
EF hand
SITE: 63-98
N-glycosylation site {N131}
sterile alpha motif
NAME: sterile alpha motif
SITE: 132-200
MOTIF: N-glycosylation site {N171}
transmembrane domain {214-234}
coiled coil {248-388}
MOTIF: glutamate-rich region {270-336}
MOTIF: glutamate residue (SEVERAL)
serine-rich region {600-629}
MOTIF: serine residue (SEVERAL)
lysine-rich region {672-685}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM 605921
UniProt Q13586
Pfam PF07647
References
UniProt :accession Q13586