cohesin subunit SA-2; SCC3 homolog 2; stromal antigen 2 (STAG2, SA2)

Function: - component of cohesin complex - phosphorylated by PLK. - dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (putative) - interacts directly with RAD21 in cohesin complex - in cohesin complexes, STAG2 is mutually exclusive with STAG1 & STAG3 Structure: - belongs to the SCC3 family - contains 1 SCD (stromalin conservative) domain Compartment: - nucleus, chromosome, centromere - associates with chromatin - before prophase, it is scattered along chromosome arms - during prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain - at anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation - in germ cells, cohesin complex dissociates from chromatin at prophase 1, & may be replaced by a meiosis-specific cohesin complex

General

nuclear protein phosphoprotein stromal antigen (STAG)

Properties

SIZE: entity length = 1231 aa MW = 141 kD COMPARTMENT: cell nucleus MOTIF: SCD {293-378} Ser phosphorylation site {S1058} Ser phosphorylation site {S1061} Ser phosphorylation site {S1065} serine-rich region {1096-1101} MOTIF: serine residue (SEVERAL) Thr phosphorylation site {T1112} Thr phosphorylation site {T1160}

Database Correlations

OMIM 604359 UniProt Q8N3U4 Pfam PF08514 Entrez Gene 10735 Kegg hsa:10735

References

UniProt :accession Q8N3U4