cohesin subunit SA-1; SCC3 homolog 1; stromal antigen 1 (STAG1, SA1)

Function: - component of cohesin complex - phosphorylated by PLK - dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (putative) - interacts directly with RAD21 in cohesin complex - in cohesin complexes, STAG1 is mutually exclusive with STAG2 & STAG3 Structure: - belongs to the SCC3 family - contains 1 SCD (stromalin conservative) domain Compartment: - nucleus, chromosome, centromere - associates with chromatin - before prophase it is scattered along chromosome arms - during prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain - at anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation

General

nuclear protein phosphoprotein stromal antigen (STAG)

Properties

SIZE: entity length = 1258 aa MW = 144 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S24} SCD {296-381} Ser phosphorylation site {S1062} serine-rich region {1065-1070} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S1065} Ser phosphorylation site {S1067} Ser phosphorylation site {S1069} Ser phosphorylation site {S1070}

Database Correlations

OMIM 604358 UniProt Q8WVM7 Pfam PF08514 Entrez Gene 10274 Kegg hsa:10274

References

UniProt :accession Q8WVM7