Stimulated by retinoic acid gene 6 protein homolog (STRA6)

Function: - may act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4) - acts by removing retinol from RBP/RBP4 & transports it across the plasma membrane, where it can be metabolized - mechanism does not depend on endocytosis - binds to RBP/RBP4 with high affinity increases cellular retinol uptake from the retinol-RBP complex Compartment: cell membrane Alternative splicing: named isoforms=4 Expression: - broad expression - in adult eye, expressed in sclera, retina, retinal pigment epithelium, & trabecular mashwork - not expressed in choroid & iris Pathology: - up-regulated in colorectal cancer cell line WiDr by administration of retinoic acid & in tumors with frequent defects in Wnt-1 signaling - defects in STRA6 are the cause of syndromic microphthalmia type-9

General

glycoprotein transmembrane 9 protein

Properties

SIZE: entity length = 667 aa MW = 74 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-50} MOTIF: N-glycosylation site {N8} transmembrane domain {51-71} cytoplasmic loop {72-100} transmembrane domain {101-121} exoplasmic loop {122-204} transmembrane domain {205-225} cytoplasmic loop {226-301} transmembrane domain {302-322} exoplasmic loop {323-324} transmembrane domain {325-345} cytoplasmic loop {346-361} transmembrane domain {362-382} exoplasmic loop {383-439} transmembrane domain {440-460} cytoplasmic loop {461-474} transmembrane domain {475-495} exoplasmic loop {496-508} transmembrane domain {509-529} cytoplasmic domain {530-667}

Database Correlations

OMIM 601186 UniProt Q9BX79

References

UniProt :accession Q9BX79