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sterol regulatory element binding protein (SREBP)

Function: - SREBP activates transcription from genes with promoters or enhancers containing the sterol regulatory elements - SREBP regulates accumulation of cholesterol by cells - in the presence of excess sterols, SREBP is maintained as an inactive precursor in the membranes of the endoplasmic reticulum. - sterol loss activates a processing pathway in which SREBP is transported to the GOLGI where it is cleaved by proteases to release the amino-terminal 1/2 of the protein from the membrane- bound precursor; this is facilitated by the SREBP cleavage activating protein (SCAP) - the cleaved SREBP then migrates to the nucleus to activate transcription of genes with promoters/enhancers containing a sterol regulatory element. [3] - genes containing sterol regulatory elements include: 1) the LDL receptor gene 2) genes encoding enzymes of cholesterol biosynthesis

Related

sterol regulatory element-binding protein cleavage-activating protein; SREBP cleavage-activating protein; SCAP (SCAP, KIAA0199, PSEC0227)

Specific

sterol regulatory element binding protein-2 (SREBP2) sterol regulatory element-binding protein 1; SREBP-1; sterol regulatory element-binding transcription factor 1 [contains: processed sterol regulatory element-binding protein 1] (SREBF1, SREBP1)

General

transcription factor (TF)

Properties

SIZE: entity length = 1141-1147 aa COMPARTMENT: cell nucleus MOTIF: acidic region {N-TERMINAL} MOTIF: acidic residue (SEVERAL) proline-rich region SITE: 50-180 MOTIF: proline residue (SEVERAL) basic helix-loop-helix {320-380} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix BOUND-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 370-400 BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper

References

  1. Yokoyama et al, SREBP-1, a basic helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75:187 1993 PMID: 8402897
  2. Hua et al, SREBP-2, a second basic helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Nat Acad Sci USA 90:11603 1993 PMID: 7903453
  3. Janowskii et al, The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 276:45408, 2001 PMID: 11577112
  4. Wikipedia; sterol regulatory element- binding protein entry http://en.wikipedia.org/wiki/sterol_regulatory_element_binding_protein