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glucocorticoid myopathy (steroid myopathy)

Etiology: - myopathy resulting from prolonged use of glucocorticoids - dexamethasone more likely than hydrocortisone or prednisone to cause steroid myopathy [2] Epidemiology: - most common endocrine-related muscle disorder Clinical manifestations: - onset may occur after 4-6 weeks of therapy - proximal muscle weakness [2] - myalgia [2] Laboratory: - serum creatine kinase: within normal limits Special laboratory: - electromyography is normal (or nearly normal) [2]

Related

endocrine myopathy glucocorticoid

General

metabolic myopathy

References

  1. Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 328
  2. Medical Knowledge Self Assessment Program (MKSAP) 15, 17, 18. American College of Physicians, Philadelphia 2009, 2015, 2018.
  3. Hanaoka BY, Peterson CA, Horbinski C, Crofford LJ. Implications of glucocorticoid therapy in idiopathic inflammatory myopathies. Nat Rev Rheumatol. 2012 Aug;8(8):448-57 PMID: 22688888