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cytochrome P450 11B (steroid-11-beta hydroxylase)
Pathology:
- deficiency may be associated with chronic hypertension due to mineralocorticoid excess [3]
Related
adrenal steroid biosynthesis
Specific
cytochrome P450 11B1 (CYP11B1, steroid-11-hydroxylase B1, steroid 11 beta-monooxygenase)
cytochrome P450 11B2 (cytochrome P450 C18, CYPC18, steroid-11-hydroxylase B2, CYP11B2, aldosterone synthase, steroid 18-hydroxylase)
General
cytochrome P450
mitochondrial membrane protein
steroid hydroxylase
Properties
SIZE: entity length = 479 aa
MW = 51 kD
COMPARTMENT: inner mitochondrial membrane
MOTIF: membrane region
active site
Database Correlations
OMIM 202010
ENZYME 1.14.14.4
References
- OMIM :accession 202010
- Williams Textbook of Endocrinology, 8th ed, JD Wilson
& DW Foster (eds), WB Saunders Co, Philadelphia PA,
1992, pg 497
- Melcescu E, Phillips J, Moll G, Subauste JS, Koch CA.
11Beta-hydroxylase deficiency and other syndromes of
mineralocorticoid excess as a rare cause of endocrine
hypertension.
Horm Metab Res. 2012 Nov;44(12):867-78. Review.
PMID: 22932914
Component-of
multienzyme complex