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statin intolerance
Classification:
- partial statin intolerance is the inability to tolerate a statin dose required to achieve a therapeutic effect, but able to tolerate lower doses
- complete statin intolerance is the inability to tolerate any statin dose
Management:
- bempedoic acid/ezetimibe may be useful in statin intolerant patients
- treatment with bempedoic acid reduces risk of major cardiovascular events [3]
- PCSK9 inhibitor may be useful in statin intolerant patients
General
intolerance
References
- Windle ML
Rapid Rx Quiz: Statin Intolerance and Related Concerns
Medscape. September 01, 2022
https://reference.medscape.com/viewarticle/979515
- Ballantyne CM, Banach M, Mancini GBJ et al
Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant
patients with hypercholesterolemia: A randomized, placebo-controlled study.
Atherosclerosis. 2018 Oct;277:195-203. Epub 2018 Jun 12.
PMID: 29910030 Free Article
- Nissen SE, Lincoff AM, Brennan D et al
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.
N Engl J Med 2023. March 4
PMID: 36876740
https://www.nejm.org/doi/10.1056/NEJMoa2215024