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stathmin-2; superior cervical ganglion-10 protein; protein SCG10 (STMN2, SCG10, SCGN10)
Function:
- may play a role in neuronal differentiation, & in modulating membrane interaction with the cytoskeleton during neurite outgrowth
- sumoylated
Structure: belongs to the stathmin family
Compartment:
- cytoplasm, perinuclear region (putative)
- cell projection, growth cone (putative)
- peripheral membrane protein, cytoplasmic side (putative)
- cell projection, axon
- associated with punctate structures in the perinuclear cytoplasm, axons, & growth cones of developing neurons
- SCG10 exists in both soluble & membrane-bound forms
Expression: neuron specific
General
phosphoprotein
stathmin family protein
Properties
SIZE: entity length = 179 aa
MW = 21 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Membrane attachment {1-26}
MOTIF: Ser phosphorylation site {S16}
Regulatory/phosphorylation domain {39-96}
MOTIF: Ser phosphorylation site {S50}
Ser phosphorylation site {S62}
Ser phosphorylation site {S73}
coiled coil {75-179}
MOTIF: Ser phosphorylation site {S80}
Ser phosphorylation site {S97}
Database Correlations
OMIM 600621
UniProt Q93045
Pfam PF00836
Entrez Gene 11075
Kegg hsa:11075
References
UniProt :accession Q93045