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atathmin; phosphoprotein p19; pp19; leukemia-associated phosphoprotein p18; oncoprotein 18; Op18; pp17; prosolin; metablastin; protein Pr22 (STMN1, LAP18, OP18)

Function: - role in regulation of microtubule system - stathmin destabilizes microtubules by preventing assembly & promoting disassembly of microtubules - implicated in the expression of innate fear & the formation of memory for learned fear [2] - MAPK phosphorylates stathmin in response to NGF [3] - phosphorylation of Ser-63 by PKA reduces tubulin binding 10-fold & suppresses microtubule polymerization inhibition activity - binds to two alpha/beta-tubulin heterodimers - phosphorylation at Ser-16 may be required for axon formation during neurogenesis - phosphorylation at Ser-16 seems to be required for neuron polarization (putative) - many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated - interacts with KIST Structure: belongs to the stathmin family Compartment: cytoplasm Expression: - ubiquitous - highest levels in brain, neurons > spinal cord & cerebellum > thymus, bone marrow, testis, & fetal liver > colon, ovary, placenta, uterus, & trachea - lowest expression is found in adult liver - within the brain, highly expressed in the amygdala & in areas afferent to the amygdala. Pathology: - present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid leukemia or chronic myeloid leukemia

Related

fear

General

phosphoprotein stathmin family protein

Properties

SIZE: MW = 17 kD entity length = 148 aa COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S16} FOR-PHOSPHORYLATION-BY: protein kinase A Ser phosphorylation site {S25} Ser phosphorylation site {S28} Ser phosphorylation site {S38} coiled coil {41-140} MOTIF: Ser phosphorylation site {S46} Ser phosphorylation site {S62} FOR-PHOSPHORYLATION-BY: protein kinase A Thr phosphorylation site {T146}

Database Correlations

OMIM 151442 UniProt P16949 Pfam PF00836 Entrez Gene 3925 Kegg hsa:3925

References

  1. Koppel et al J Biol Chem 265:3703 1990
  2. Shumyatsky GP et al, Stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell 2005; 123:697 PMID: 16286011
  3. swiss-prot :accession P16949