Search
Stanniocalcin-1; STC-1 (STC1 STC)
Function:
- stimulates renal phosphate reabsorption in fish & rats
- prevents hypercalcemia in fish
Structure: belongs to the stanniocalcin family
Compartment: secreted
Expression:
- expressed in most tissues
- highest levels in ovary, prostate, heart, kidney & thyroid
- in the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule & in the collecting tubule
- not detected in the brain, liver, spleen, peripheral blood leukocytes & adrenal medulla
General
glycoprotein
hormone
Properties
SIZE: entity length = 247 aa
MW = 28 kD
MOTIF: signal sequence {1-17}
cysteine residue {C45}
MODIFICATION: cysteine residue {C59}
cysteine residue {C54}
MODIFICATION: cysteine residue {C74}
cysteine residue {C59}
MODIFICATION: cysteine residue {C45}
N-glycosylation site {N62}
cysteine residue {C65}
MODIFICATION: cysteine residue {C114}
cysteine residue {C74}
MODIFICATION: cysteine residue {C54}
cysteine residue {C98}
MODIFICATION: cysteine residue {C128}
cysteine residue {C114}
MODIFICATION: cysteine residue {C65}
cysteine residue {C128}
MODIFICATION: cysteine residue {C98}
cysteine residue {C135}
MODIFICATION: cysteine residue {C170}
cysteine residue {C170}
MODIFICATION: cysteine residue {C135}
cysteine residue {C202}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Database Correlations
OMIM 601185
UniProt P52823
Pfam PF03298
Entrez Gene 6781
Kegg hsa:6781
References
UniProt :accession P52823