stage selector protein complex (SSP complex)

Function: - binds to stage selector element (SSE) in proximal gamma-globin promoter - contributes to the preferential expression of the gamma-globin gene in fetal erythroid cells by facilitating interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR) Structure: - subunits: TFCP2, NF-E4 (2)

Properties

SUBUNITS: alpha-globin transcription factor CP2 COMPARTMENT: cell nucleus MOTIF: binding site SITE: 133-395 FOR-BINDING-OF: deoxyribonucleic acid (DNA) MOTIF: proline-rich region SITE: 314-319 MOTIF: proline residue (SEVERAL) glutamine-rich region {396-413} MOTIF: glutamine residue (SEVERAL) transcription factor NF-E4 (2) COMPARTMENT: cell nucleus

References

UniProt :accession Q12800

Components

alpha-globin transcription factor CP2 (transcription factor LSF, SAA3 enhancer factor, TFCP2, LSF, SEF) transcription factor NF-E4 (NFE4)