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stabilin 1 (FEEL-1 protein, MS-1 antigen, fasciclin EGF-like - laminin-type E-like & link domain-containing scavenger receptor 1, STAB1, FEEL1, KIAA0246)
Function:
- acts as a scavenger receptor for acetylated low density lipoprotein
- binds to both Gram-positive & Gram-negative bacteria & may play a role in defense against bacterial infection
- when inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis
- role in delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system
- interacts with CHID1
Structure:
- contains 16 EGF-like domains
- contains 7 FAS1 domains
- contains 2 laminin EGF-like domains
- contains 1 link domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- high levels found in spleen, lymph node, liver & placenta
- also expressed in endothelial cells
General
glycoprotein
scavenger receptor
Properties
SIZE: MW = 275 kD
entity length = 2570 aa
COMPARTMENT: cellular membrane
MOTIF: EGF domain {110-2174} (16)
MOTIF: cysteine residue {C112}
MODIFICATION: cysteine residue {C126}
cysteine residue {C120}
MODIFICATION: cysteine residue {C136}
cysteine residue {C126}
MODIFICATION: cysteine residue {C112}
N-glycosylation site {N133}
cysteine residue {C136}
MODIFICATION: cysteine residue {C120}
cysteine residue {C138}
MODIFICATION: cysteine residue {C147}
cysteine residue {C147}
MODIFICATION: cysteine residue {C138}
N-glycosylation site (SEVERAL)
FAS1 {356-2459} (7)
MOTIF: N-glycosylation site {N413}
LINK {2206-2301}
MOTIF: N-glycosylation site {N2222}
cysteine residue {C2230}
MODIFICATION: cysteine residue {C2299}
cysteine residue {C2254}
MODIFICATION: cysteine residue {C2275}
N-glycosylation site {N2261}
cysteine residue {C2275}
MODIFICATION: cysteine residue {C2254}
N-glycosylation site {N2290}
cysteine residue {C2299}
MODIFICATION: cysteine residue {C2230}
transmembrane domain {2479-2499}
Database Correlations
OMIM 608560
UniProt Q9NY15
PFAM correlations
Kegg hsa:2316
References
UniProt :accession Q9NY15