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interleukin-1 receptor-like 1; protein ST2; growth stimulation expressed gene 2 protein (IL1RL1, DER4, ST2, T1)
Function:
- receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, & TRAF6, followed by phosphorylation of MAPK3/ERK1 &/or MAPK1/ERK2, MAPK14, & MAPK8
- possibly involved in helper T-cell function
- interacts with MYD88, IRAK1, IRAK4, & TRAF6
Structure:
- belongs to the interleukin-1 receptor family
- contains 3 Ig-like C2-type domains
- contains 1 TIR domain
Compartment:
- isoform C: cell membrane
- single-pass type 1 membrane protein
- isoform B: secreted
Alternative splicing:
- named isoforms=3; ST2L, ST2S, ST2V
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon & small intestine
- isoform A is prevalently expressed in the lung, testis, placenta, stomach & colon
- isoform B is more abundant in the brain, kidney & the liver
- isoform C is not detected in brain, heart, liver, kidney & skeletal muscle
Laboratory:
- growth stimulation expressed gene 2 analysis
General
cell surface receptor
glycoprotein
secreted protein
Properties
SIZE: entity length = 556 aa
MW = 63 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
immunoglobulin superfamily domain {19-103}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C87}
N-glycosylation site {N54}
cysteine residue {C87}
MODIFICATION: cysteine residue {C36}
N-glycosylation site {N95}
N-glycosylation site {N101}
immunoglobulin superfamily domain {114-197}
MOTIF: cysteine residue {C133}
MODIFICATION: cysteine residue {C181}
N-glycosylation site {N140}
cysteine residue {C181}
MODIFICATION: cysteine residue {C133}
N-glycosylation site {N191}
immunoglobulin superfamily domain {212-319}
MOTIF: N-glycosylation site {N232}
cysteine residue {C235}
MODIFICATION: cysteine residue {C303}
N-glycosylation site {N254}
N-glycosylation site {N273}
cysteine residue {C303}
MODIFICATION: cysteine residue {C235}
transmembrane domain {329-349}
TIR domain {375-538}
Database Correlations
OMIM 601203
UniProt Q01638
PFAM correlations
Entrez Gene 9173
Kegg hsa:9173
References
UniProt :accession Q01638