protein SSX2; synovial sarcoma, X breakpoint 2; tumor antigen HOM-MEL-40; cancer/testis antigen 5.2; CT5.2 (SSX2, SSX2A, SSX2B)

Function: - could act as a modulator of transcription - interacts via its N-terminal region with RAB3IP & SSX2IP Structure: - belongs to the SSX family - contains 1 KRAB-related domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed at high level in the testis - expressed at low level in thyroid - not detected in tonsil, colon, lung, spleen, prostate, kidney, striated & smooth muscles - detected in rhabdomyosarcoma & fibrosarcoma cell lines - not detected in mesenchymal & epithelial cell lines Pathology: - chromosomal t(X;18)(p11.2;q11.2) involving SSX2 may be a cause of synovial sarcoma - the translocation is specifically found in more than 80% of synovial sarcomas - fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity - heterogeneity in the position of the breakpoint can occur (low frequency)

General

nuclear protein SSX family protein

Properties

SIZE: entity length = 188 aa MW = 22 kD COMPARTMENT: cell nucleus MOTIF: SSX2IP interaction {1-80} Krueppel-associated box NAME: Krueppel-associated box SITE: 20-83 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 RAB3IP interaction {25-80} breakpoint {68-69} breakpoint {110-111}

Database Correlations

OMIM 300192 UniProt Q16385 PFAM correlations LOCUS-LINK correlations KEGG correlations

References

UniProt :accession Q16385