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SRRM/SFRS/SNRP pre-mRNA splicing complex
Structure:
- consists of: SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 & SRRM2
General
molecular complex
Properties
SUBUNITS: splicing factor arginine/serine-rich 4
COMPARTMENT: cell nucleus
MOTIF: RNA-binding motif
SITE: 2-72
FOR-BINDING-OF: ribonucleic acid
glycine-rich region {72-97}
RNA-binding motif
SITE: 104-177
FOR-BINDING-OF: ribonucleic acid
phosphorylation site
arginine/serine-rich region (RS domain) {179-494}
MOTIF: serine residue (SEVERAL)
arginine residue (SEVERAL)
splicing factor arginine/serine-rich 5
COMPARTMENT: cell nucleus
MOTIF: RNA-binding motif
SITE: 4-74
FOR-BINDING-OF: ribonucleic acid
glycine-rich region {78-83}
RNA-binding motif
SITE: 108-181
FOR-BINDING-OF: ribonucleic acid
arginine/serine-rich region (RS domain) {182-267}
MOTIF: serine residue (SEVERAL)
arginine residue (SEVERAL)
SNRP70
U2-A' protein
MOTIF: RNP motif
NAME: RNP motif (2)
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
serine/arginine repetitive matrix protein 1
COMPARTMENT: cell nucleus
MOTIF: domain {1-156}
MOTIF: binding site
SITE: 1-151
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
RNA
Ser phosphorylation site {S10}
PWI {45-118}
arginine-rich region {163-726}
MOTIF: arginine residue (SEVERAL)
proline-rich region
SITE: 210-417
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S211}
Thr phosphorylation site {T220}
serine-rich region {278-756}
MOTIF: Ser phosphorylation site (11) {389-549}
domain {300-688}
proline-rich region
SITE: 550-799
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site (10) {560-616}
Ser phosphorylation site (10) {626-775}
Ser phosphorylation site {S781}
lysine-rich region {809-835}
MOTIF: lysine residue (SEVERAL)
alanine-rich region {836-865}
MOTIF: alanine residue (SEVERAL)
serine/arginine repetitive matrix protein 2
COMPARTMENT: cell nucleus
MOTIF: coiled coil {60-92}
Ser phosphorylation site {S142}
serine-rich region {177-2731}
MOTIF: serine residue (SEVERAL)
lysine-rich region {186-246}
MOTIF: lysine residue (SEVERAL)
binding site
SITE: 197-259
FOR-BINDING-OF: ribonucleic acid
Ser phosphorylation site {S250}
Thr phosphorylation site {T252}
Thr phosphorylation site {T274}
Ser phosphorylation site {S297}
proline-rich region
SITE: 350-447
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S351}
Ser phosphorylation site {S353}
Thr phosphorylation site {T367}
Ser phosphorylation site {S424}
arginine-rich region {462-816}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S778}
Ser phosphorylation site {S780}
Ser phosphorylation site {S783}
Ser phosphorylation site {S820}
Ser phosphorylation site {S857}
Thr phosphorylation site {T866}
Ser phosphorylation site {S871}
Ser phosphorylation site {S876}
Ser phosphorylation site {S901}
Thr phosphorylation site {T903}
Ser phosphorylation site {S908}
Ser phosphorylation site {S914}
Ser phosphorylation site {S924}
Ser phosphorylation site {S952}
Ser phosphorylation site {S954}
Ser phosphorylation site {S988}
Ser phosphorylation site {S994}
Thr phosphorylation site {T1003}
Thr phosphorylation site {T1043}
Ser phosphorylation site {S1069}
Ser phosphorylation site {S1072}
Ser phosphorylation site {S1073}
Ser phosphorylation site {S1079}
Ser phosphorylation site {S1083}
Ser phosphorylation site {S1103}
Ser phosphorylation site {S1124}
Ser phosphorylation site {S1132}
Ser phosphorylation site {S1179}
Ser phosphorylation site {S1188}
Ser phosphorylation site {S1214}
Ser phosphorylation site {S1219}
Ser phosphorylation site {S1320}
Ser phosphorylation site {S1326}
Ser phosphorylation site {S1329}
Ser phosphorylation site {S1397}
Ser phosphorylation site {S1404}
Ser phosphorylation site {S1421}
Ser phosphorylation site {S1423}
Ser phosphorylation site {S1441}
Ser phosphorylation site {S1443}
Ser phosphorylation site {S1444}
Thr phosphorylation site {T1453}
Ser phosphorylation site {S1483}
Thr phosphorylation site {T1492}
Ser phosphorylation site {S1499}
Ser phosphorylation site {S1501}
Ser phosphorylation site {S1502}
Thr phosphorylation site {T1511}
Ser phosphorylation site {S1517}
Ser phosphorylation site {S1519}
Ser phosphorylation site {S1522}
Ser phosphorylation site {S1559}
Ser phosphorylation site {S1579}
Ser phosphorylation site {S1581}
Ser phosphorylation site {S1582}
Ser phosphorylation site {S1600}
Ser phosphorylation site {S1601}
Ser phosphorylation site {S1618}
Ser phosphorylation site {S1621}
arginine-rich region {1666-2089}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S1842}
Thr phosphorylation site {T1844}
Ser phosphorylation site {S1878}
Thr phosphorylation site {T1880}
Thr phosphorylation site {T1962}
Ser phosphorylation site {S2011}
Ser phosphorylation site {S2032}
Thr phosphorylation site {T2034}
Ser phosphorylation site {S2044}
Ser phosphorylation site {S2046}
Ser phosphorylation site {S2067}
Ser phosphorylation site {S2071}
Thr phosphorylation site {T2092}
Thr phosphorylation site {T2104}
alanine-rich region {2182-2378}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S2272}
Thr phosphorylation site {T2289}
Thr phosphorylation site {T2291}
Thr phosphorylation site {T2316}
Ser phosphorylation site {S2335}
Ser phosphorylation site {S2382}
Ser phosphorylation site {S2398}
Ser phosphorylation site {S2407}
Thr phosphorylation site {T2409}
Ser phosphorylation site {S2426}
Ser phosphorylation site {S2449}
Ser phosphorylation site {S2581}
arginine-rich region {2673-2750}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S2692}
Ser phosphorylation site {S2694}
Ser phosphorylation site {S2714}
References
UniProt :accession Q9UQ35
Components
serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kD; SRm160; Ser/Arg-related nuclear matrix protein (SRRM1 SRM160)
serine/arginine repetitive matrix protein 2 (serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kD, Ser/Arg-related nuclear matrix protein, SR-related nuclear matrix protein of 300 kD, splicing coactivator subunit SRm300, 300 kD nuclear matrix antigen, SRRM2, KIAA0324, SRL300, SRM300, HSPC075)
splicing factor arginine/serine-rich 4; pre-mRNA splicing factor (SRP75, SRSF4, SRP001LB)
splicing factor arginine/serine-rich 5; pre-mRNA splicing factor SRP40; delayed-early protein HRS (SFRS5, SRSF5, SRP40, HRS)
U2-A' protein (SNRPA1)