signal recognition peptide [SRP] receptor or docking protein

Function: - ensures correct targeting of nascent secretory proteins to the endoplasmic reticulum membrane system Structure: - heterodimer of an alpha (SRPR) & a beta (SRPRB) chain

General

docking protein membrane protein multisubunit protein receptor

Properties

COMPARTMENT: endoplasmic reticulum MOTIF: ligand-binding site membrane region SUBUNITS: signal recognition particle receptor subunit alpha MOTIF: Tyr phosphorylation site {Y261} Ser phosphorylation site {S296} Ser phosphorylation site {S297} Ser phosphorylation site {S298} GTP-binding site SITE: 425-432 GTP-binding site SITE: 520-524 GTP-binding site SITE: 588-591 signal recognition particle receptor subunit beta MOTIF: transmembrane domain {37-57} GTP-binding site SITE: 71-78 GTP-binding site SITE: 117-121 GTP-binding site SITE: 180-183

References

- Bourne HR et al, The GTPase superfamily: a conserved switch for diverse cell functions Nature 348:125 1990 PMID: 2122258

Components

signal recognition particle receptor subunit alpha; SR-alpha; docking protein alpha; DP-alpha (SRPR) signal recognition particle receptor subunit beta; SR-beta; protein APMCF1 (SRPRB)