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elk4 proto-oncogene protein; serum response factor [SRF] accessory protein-1; SAP-1 (ELK4)
Function:
- forms a ternary complex with the serum response factor (SRF) over c-fos Serum Response Element
- requires DNA-bound SRF for ternary complex formation & makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment: nucleus
Alternative splicing:
- named isoforms=2
- SRF accessory protein-1 alpha (SRF1A) - 58 kD
- SRF accessory protein-1 beta (SRF1B) - 62 kD
Related
SRF-accessory protein-1 (SAP1) gene
General
Ets family protein
Properties
SIZE: entity length = 431 aa
MW = 47 kD
COMPARTMENT: cell nucleus
MOTIF: ETS domain
NAME: ETS domain
SITE: 5-85
Database Correlations
OMIM 600246
UniProt P28324
Pfam PF00178
Entrez Gene 2005
Kegg hsa:2005
References
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
- UniProt :accession P28324