SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP, C14orf156, DC23, DC50, PD04872)

Function: - RNA-binding protein - nuclear receptor corepressor - binds SRA RNA, & represses SRA-mediated nuclear receptor coactivation - binds STR7 loop of SRA RNA - able to repress glucocorticoid receptor, androgen receptor, thyroid receptor & VDR-mediated transactivation Structure: contains 1 RRM domain (RNA recognition motif) Compartment: - mitochondrion, nucleus - predominantly mitochondrial, some fraction is nuclear - in the nucleus, recruited to nuclear receptor target promoters Expression: - ubiquitously expressed, with highest level in heart, liver, skeletal muscle & testis

General

mitochondrial protein nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: MW = 12 kD entity length = 109 aa COMPARTMENT: mitochondria cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 19-103 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S102}

Database Correlations

UniProt Q9GZT3 Pfam PF00076

References

UniProt :accession Q9GZT3