serpin B4; squamous cell carcinoma antigen 2; SCCA-2; leupin (SERPINB4, SCCA2)

Function: - may act as a protease inhibitor to modulate the host immune response against tumor cells Structure: belongs to the serpin family, Ov-serpin subfamily Compartment: - cytoplasm - seems to also be secreted in plasma by cancerous cells but at a low level Expression: squamous cells

General

glycoprotein serine protease inhibitor; serpin

Properties

SIZE: entity length = 390 aa MW = 45 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl serpin motif FOR-BINDING-OF: serine protease glycosylation site peptide motif {354-355} INHIBITS: serine protease

Database Correlations

OMIM 600518 UniProt P48594 Pfam PF00079 Entrez Gene 6318 Kegg hsa:6318

References

UniProt :accession P48594