Search
squalene synthetase (farnesyl-diphosphate farnesyltransferase, FDFT1, SQS)
Function:
- steroid biosynthesis
- terpenoid biosynthesis
2 farnesyl diphosphate diphosphate + presqualene diphosphate
presqualene diphosphate + NADH/NADPH
squalene + diphosphate + NAD+/NADP+
Cofactor: Mg+2
Structure:
- monomer (putative)
- belongs to the phytoene/squalene synthetase family
Compartment:
- endoplasmic reticulum membrane
Interactions
molecular events
Related
cholesterol biosynthesis
squalene synthetase gene
General
membrane protein
oxidoreductase
prenyltransferase
Properties
SIZE: entity length = 417 aa
MW = 48 kD
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: cofactor-binding site
COFACTOR-BOUND: NADPH
transmembrane domain {284-304}
transmembrane domain {384-404}
SUBUNITS: prenyl transferase-alpha
MOTIF: proline-rich region
SITE: 22-31
MOTIF: proline residue (SEVERAL)
PFTA {112-146}
PFTA {147-180}
PFTA {181-215}
PFTA {216-249}
PFTA {255-289}
prenyl transferase-beta
MOTIF: binding site
FOR-BINDING-OF: ras superfamily protein
GENE: squalene synthetase gene
Database Correlations
OMIM 184420
UniProt P37268
Entrez Gene 2222
ENZYME 2.5.1.21
References
UniProt :accession P37268
Components
CAAX farnesyltransferase alpha subunit (FNTA, RAS proteins prenyltransferase-alpha)
prenyltransferase-beta