spondin-2 (Mindin, differentially expressed in cancerous & non-cancerous lung cells 1, DIL-1, SPON2, DIL1, UNQ435/PRO866)

Function: 1) cell adhesion protein 2) promotes adhesion & outgrowth of hippocampal embryonic neurons 3) binds directly to bacteria & their components 4) functions as an opsonin for macrophage phagocytosis of bacteria 5) essential in the initiation of the innate immune response 6) unique pattern-recognition molecule in the extracellular matrix for microbial pathogens Compartment: secreted, extracellular matrix Expression: - expressed in normal lung tissues but not in lung carcinoma cell lines

General

cell adhesion protein spondin

Properties

SIZE: MW = 36 kD entity length = 331 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-26} SPONDIN {31-221} focal adhesion site TSP TYPE-1 {277-331}

Database Correlations

OMIM 605918 UniProt Q9BUD6 PFAM correlations

References

UniProt :accession Q9BUD6