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spondin-1 (F-spondin, vascular smooth muscle cell growth-promoting factor, SPON1, KIAA0762, VSGP)
Function:
1) cell adhesion protein
2) promotes attachment of spinal cord & sensory neuron cells
3) promotes outgrowth of neurites in vitro
4) growth & guidance of axons in both the spinal cord and the peripheral nervous system (putative)
5) major factor for vascular smooth muscle cell
6) binds to the central extracellular domain of APP
7) inhibits beta-secretase cleavage of APP
Compartment: secreted
Expression:
- expressed in lung > brain, heart, kidney, liver, testis > pancreas, skeletal muscle, ovary
- not expressed in spleen
General
cell adhesion protein
glycoprotein
spondin
Properties
SIZE: MW = 91 kD
entity length = 807 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-28}
REELIN {29-194}
SPONDIN {195-388}
MOTIF: N-glycosylation site {N214}
TSP TYPE-1 1 {442-495}
TSP TYPE-1 2 {501-555}
MOTIF: cysteine residue {C502}
MODIFICATION: cysteine residue {C538}
cysteine residue {C513}
MODIFICATION: cysteine residue {C517}
cysteine residue {C517}
MODIFICATION: cysteine residue {C513}
cysteine residue {C538}
MODIFICATION: cysteine residue {C502}
cysteine residue {C548}
MODIFICATION: cysteine residue {C554}
cysteine residue {C554}
MODIFICATION: cysteine residue {C548}
TSP TYPE-1 3 {558-611}
MOTIF: cysteine residue {C559}
MODIFICATION: cysteine residue {C595}
cysteine residue {C570}
MODIFICATION: cysteine residue {C574}
cysteine residue {C574}
MODIFICATION: cysteine residue {C570}
cysteine residue {C595}
MODIFICATION: cysteine residue {C559}
cysteine residue {C605}
MODIFICATION: cysteine residue {C610}
cysteine residue {C610}
MODIFICATION: cysteine residue {C605}
TSP TYPE-1 4 {614-666}
MOTIF: cysteine residue {C615}
MODIFICATION: cysteine residue {C650}
cysteine residue {C626}
MODIFICATION: cysteine residue {C630}
cysteine residue {C630}
MODIFICATION: cysteine residue {C626}
cysteine residue {C650}
MODIFICATION: cysteine residue {C615}
cysteine residue {C660}
MODIFICATION: cysteine residue {C665}
cysteine residue {C665}
MODIFICATION: cysteine residue {C660}
TSP TYPE-1 5 {668-721}
MOTIF: N-glycosylation site {N681}
TSP TYPE-1 6 {754-806}
Database Correlations
OMIM 604989
UniProt Q9HCB6
PFAM correlations
References
UniProt :accession Q9HCB6