spliceosome C complex

Function: - RNA splicing - activated spliceosome complex - the U4/U5/U6 tri-snRNP is recruited to the assembling spliceosome 'complex A' to form 'complex B' & following several rearrangements, 'Complex C' (the splicesome) is activated for catalysis Structure: - consists of: - hnRNA, U1 snRNP, U2 snRNP, U4 snRNP, U5 snRNP, U6 snRNP & nuclear proteins - AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2, ZCCHC8 Notes: see spliceosome for spliceosome assembly

Properties

STATE: Inactive MOTIF: active site

References

UniProt :accession Q96D31

Components

116 kD U5 small nuclear ribonucleoprotein (EFTUD2) ATP-dependent RNA helicase DDX23; 100 kD U5 snRNP-specific protein; DEAD box protein 23; PRP28 homolog; U5-100kD (DDX23) ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD box protein abstrakt homolog (DDX41, ABS) ATP-dependent RNA helicase DHX35; DEAH box protein 35 (DHX35, C20orf15, DDX35) ATP-dependent RNA helicase DHX8; DEAH box protein 8; RNA helicase HRH1 (DHX8 DDX8) cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein (CDC5L, KIAA0432, PCDC5RP) crooked neck-like protein 1 (crooked neck homolog, hCrn, CRNKL1, CRN, CGI-201, MSTP021) cyclophilin E (cyclophilin 3, 33kD peptidyl-prolyl cis-trans isomerase, cyclophilin 33, rotamase E, PPIE, CYP33) DEAD box protein 5; ATP-dependent RNA helicase DDX5; RNA helicase p68 (DDX5, G17P1, HELR, HLR1) DiGeorge syndrome critical region 14; DiGeorge syndrome critical region 13; DiGeorge syndrome protein H; protein DGCR14; DGS-H; protein ES2 (DGCR14, DGCR13, DGSH, DGSI, ES2) G patch domain-containing protein 1 (evolutionarily conserved G-patch domain-containing protein, GPATCH1, ECGP, GPATC1) heterogeneous nuclear ribonucleoprotein-A1 (hnRNP-A1) heterogeneous nuclear ribonucleoprotein A3; hnRNP A3 (HNRNPA3, HNRPA3) heterogeneous nuclear ribonucleoprotein F; hnRNP F; nucleolin-like protein mcs94-1; contains: heterogeneous nuclear ribonucleoprotein F, N-terminally processed (HNRNPF, HNRPF) heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome; glycoprotein p43; contains: heterogeneous nuclear ribonucleoprotein G, N-terminally processed (RBMX, HNRPG, RBMXP1) heterogeneous nuclear ribonucleoprotein H; hnRNP H; contains: heterogeneous nuclear ribonucleoprotein H, N-terminally processed (HNRNPH1, HNRPH, HNRPH1) heterogeneous nuclear ribonucleoprotein K; hnRNP K; transformation up-regulated nuclear protein; TUNP (HNRNPK, HNRPK) heterogeneous nuclear ribonucleoprotein M; hnRNP M (HNRNPM, HNRPM, NAGR1) heterogeneous nuclear ribonucleoprotein Q (hnRNP-Q, synaptotagmin-binding cytoplasmic RNA-interacting protein, glycine- & tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, SYNCRIP, HNRPQ, NSAP1) heterogeneous nuclear ribonucleoprotein R; hnRNP R (HNRNPR, HNRPR) heterogeneous nuclear ribonucleoprotein U; hnRNP U; scaffold attachment factor A; SAF-A; p120; pp120 (HNRNPU, HNRPU, SAFA, U211) heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) heterogeneous nuclear ribonucleoprotein-C1/C2 (hnRNP-C1/C2) Intron-binding protein aquarius (intron-binding protein of 160 kD, IBP160, AQR, KIAA0560) mitogen-activated protein kinase organizer 1; WD repeat domain-containing protein 83; MAPK organizer 1 (WDR83, MORG1) nucampholin homolog (CWC22, fSAPb, NCM, KIAA1604) peptidyl-prolyl cis-trans isomerase-like 1 (PPIase, rotamase, PPIL1, CYPL1, CGI-124, UNQ2425/PRO4984) peptidyl-prolyl cis-trans isomerase-like 3 (PPIase, Rotamase, cyclophilin-like protein PPIL3, cyclophilin J, CyPJ, PPIL3) peptidylprolyl isomerase domain and WD repeat-containing protein 1 (PPWD1, KIAA0073) pinin (140 kD nuclear & cell adhesion-related phosphoprotein, domain-rich serine protein, DRS-protein, DRSP, melanoma metastasis clone A protein, desmosome-associated protein, SR-like protein, nuclear protein SDK3, PNN, DRS, MEMA) pleiotropic regulator 1 (PLRG1) polyadenylate-binding protein 1; poly(A)-binding protein 1; PABP 1 (PABPC1, PAB1, PABP1, PABPC2) pre-mRNA splicing factor PRP17 (cell division cycle 40 homolog, EH-binding protein 3, Ehb3) pre-mRNA-processing factor 19 (PRP19/PSO4 homolog, hPso4, nuclear matrix protein 200, senescence evasion factor, PRPF19, NMP200, PRP19, SNEV) pre-mRNA-processing factor 6 (PRP6 homolog, U5 snRNP-associated 102 kD protein, U5-102 kD protein, PRPF6, C20orf14) pre-mRNA-processing-splicing factor 8 (splicing factor Prp8, PRP8 homolog, 220 kD U5 snRNP-specific protein, p220, PRPF8, PRPC8) pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; ATP-dependent RNA helicase DHX38; DEAH box protein 38 (DHX38, DDX38, KIAA0224, PRP16) Pre-mRNA-splicing factor ISY1 homolog (ISY1 KIAA1160) pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22 zinc finger CCCH domain-containing protein 16, RBM22, ZC3H16, 199G4) pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor, p29, SYF2, CBPIN, GCIPIP) protein C19orf29; renal carcinoma antigen NY-REN-24 (CACTIN) protein FRG1 (facioscapulohumeral muscular dystrophy region gene 1 protein, FSHD region gene 1 protein, FRG1) protein mago nashi homolog (MAGOH) RNA-binding protein 8A; RNA-binding motif protein 8A; ribonucleoprotein RBM8A; RNA-binding protein Y14; binder of OVCA1-1; BOV-1 (RBM8A, RBM8, HSPC114, MDS014) RNA-binding protein Raly (hnRNP associated with lethal yellow homolog, autoantigen p542, RALY, P542, Ay protein) serine/arginine repetitive matrix protein 1; SR-related nuclear matrix protein of 160 kD; SRm160; Ser/Arg-related nuclear matrix protein (SRRM1 SRM160) serine/arginine repetitive matrix protein 2 (serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kD, Ser/Arg-related nuclear matrix protein, SR-related nuclear matrix protein of 300 kD, splicing coactivator subunit SRm300, 300 kD nuclear matrix antigen, SRRM2, KIAA0324, SRL300, SRM300, HSPC075) serine/threonine protein kinase PRP4 homolog; PRP4 kinase; PRP4 pre-mRNA-processing factor 4 homolog (PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K) small nuclear ribonucleoprotein F; snRNP-F; Sm protein F (SmF, snRPF, snRNPF) small nuclear ribonucleoprotein G; snRNP-G; Sm protein G (SmG, SNRPG) small nuclear ribonucleoprotein [snRNP] polypeptide SmB/B' small nuclear ribonucleoprotein Sm D1; Sm-D1; Sm-D autoantigen; snRNP core protein D1 (SNRPD1) small nuclear ribonucleoprotein Sm D2; snRNP core protein D2; Sm-D2 (SNRPD2) small nuclear ribonucleoprotein Sm D3; snRNP core protein D3; Sm-D3 (SNRPD3) small nuclear ribonucleoprotein U2B'' (SNRPB2) SNW domain-containing protein 1; nuclear protein skiP; nuclear receptor coactivator NCoA-62; ski-interacting protein (SNW1, SKIIP, SKIP) splicing factor 3A subunit 1 (spliceosome associated protein 114, SAP 114, SF3a120, SF3A1) splicing factor 3A subunit 2 (spliceosome associated protein 62, SAP 62, SF3a66, SF3A2) splicing factor 3A subunit 3 (spliceosome associated protein 61, SAP 61, SF3a60, SF3A3) splicing factor 3B subunit 1 (spliceosome associated protein 155, SAP 155, SF3b155, pre-mRNA splicing factor SF3b 155 kD subunit, SF3B1) splicing factor 3B subunit 2 (spliceosome associated protein 145, SAP 145, SF3b150, pre-mRNA splicing factor SF3b 145 kD subunit, SF3B2) splicing factor 3B subunit 3 (spliceosome associated protein 130, SAP 130, SF3b130, pre-mRNA splicing factor SF3b 130 kD subunit, SF3B4) splicing factor U2 auxiliary factor [U2-AF] p35; U2-AF small subunit (U2AF1) superkiller viralicidic activity 2-like 2; ATP-dependent helicase SKIV2L2 (SKIV2L2, KIAA0052, Mtr4) THO complex subunit 4; Tho4; Ally of AML-1 & LEF-1; transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF (THOC4, ALY, BEF, ALYREF) tuftelin-interacting protein 11 (TFIP11) U1/U2-E protein (snRPE) U2-A' protein (SNRPA1) U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kD protein, squamous cell carcinoma antigen recognized by T cells 1, SART-1, hSART-1, hSnu66, SART1) U6 snRNA-associated Sm-like protein LSm2 (small nuclear ribonuclear protein D homolog, G7b, SnRNP core SM-like protein SM-x5, LSM2, C6orf28, G7B) U6 snRNA-associated Sm-like protein LSm3 (MDS017) WD repeat protein 57; Prp8-binding protein; hPRP8BP; U5 snRNP-specific 40 kD protein; 38 kD-splicing factor (WDR57, SNRNP40, PRP8BP, SFP38) XPA-binding protein 2 (HCNP protein) (XAB2 HCNP KIAA1177 PP3898) zinc finger CCHC domain-containing protein 8 (ZCCHC8)