spleen tyrosine kinase (Syk)

Function: - tyrosine kinase - activated by integrin-beta 1 & integrin-beta 3 cross-linking [1] - apparently associates with surface immunoglobulin (sIg) B-cell antigen receptor & with high affinity IgE receptor in mast cells & is activated by ligand binding to these receptors - role in proliferation, differentiation, & phagocytosis Structure: - contains 2 SH2 domains Expression: - expressed in hematopoietic cells Pharmacology: - fostamatinib is a small molecule Syk kinase inhibitor with potential anti-inflammatory & immunomodulating activities

Properties

COMPARTMENT: cellular compartment CELL: unspecified cell type WITHIN: spleen STATE: active state MOTIF: Tyr phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site MISC-INFO: RECOGNITION-MOTIF :SEQUENCE EDAE[Y*]AARRRG :REF " - Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044"

Database Correlations

OMIM 600085 UniProt P43405 KEGG correlations