spindle & kinetochore-associated protein 1 (SKA1 C18orf24)

Function: - required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint - role in maintenance of metaphase plate &/or spindle checkpoint silencing - required for SKA2/FAM33A stability - interacts directly & forms a complex with SKA2/FAM33A Structure: belongs to the SKA1 family Compartment: - spindle, kinetochore - localizes to both mitotic spindle & kinetochore-associated proteins - associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase & then vanishes in telophase

Properties

SIZE: MW = 29 kD entity length = 255 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {49-91}

Database Correlations

UniProt Q96BD8 Pfam PF07160

References

UniProt :accession Q96BD8