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spike glycoprotein

Structure: - 3D structure [3] Pathology: - attachment protein for SARS viruses - attaches to ACE2 in the case of SARS CoV, including SARS CoV2 - requires a transmembrane protease TMPRSS2 in order for the virus enter a cell - spike glycoproteins are synthesized as precursors with proteolysis facilitating refolding required to create stable virus-cell linkages & membrane coalescence [2]

Related

moesin; membrane-organizing extension spike protein (MSN)

General

glycoprotein viral protein

Properties

MOTIF: glycosylation site

References

  1. Hoffmann M, Kleine-Weber H, Schroeder S SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. PMID: 32142651
  2. UniProt :accession Q9BYF1
  3. Wrapp D, Wang N, Corbett KS et al Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 13 Mar 2020: Vol. 367, Issue 6483, pp. 1260-1263 PMID: 32075877 https://science.sciencemag.org/content/367/6483/1260