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sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5; endothelial differentiation G-protein coupled receptor 5 (S1PR2, EDG5)
Function:
- receptor for the lysosphingolipid sphingosine 1-phosphate (S1P)
- when expressed in rat HTC4 hepatoma cells, capable of mediating S1P-induced cell proliferation & suppression of apoptosis
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
glycoprotein
sphingosine 1-phosphate receptor; S1P receptor (S1PR)
Properties
SIZE: MW = 39 kD
entity length = 353 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-34}
MOTIF: N-glycosylation site {N19}
transmembrane domain {35-59}
cytoplasmic loop {60-66}
transmembrane domain {67-95}
exoplasmic loop {96-109}
transmembrane domain {110-128}
cytoplasmic loop {129-147}
transmembrane domain {148-173}
exoplasmic loop {174-189}
transmembrane domain {190-210}
cytoplasmic loop {211-233}
transmembrane domain {234-255}
exoplasmic loop {256-271}
transmembrane domain {272-292}
cytoplasmic domain {293-353}
MOTIF: cysteine residue {C305}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 605111
UniProt O95136
Pfam PF00001
Kegg hsa:9294
References
UniProt :accession O95136