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sphingosine-1-phosphate lyase 1 (SP-lyase, hSPL, sphingosine-1-phosphate aldolase, SGPL1, KIAA1252)
Function:
1) sphingolipid metabolism
2) cleaves phosphorylated sphingoid bases, i.e. sphingosine-1-phosphate, into fatty aldehydes & phosphoethanolamine
3) elevates stress-induced ceramide production
4) promotes apoptosis
sphinganine-1-phosphate
phosphoethanolamine + palmitaldehyde
Cofactor: pyridoxal phosphate
Compartment: endoplasmic reticulum membrane
Expression: expressed in liver, kidney
General
lyase
Properties
SIZE: MW = 64 kD
entity length = 568 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {41-61}
cofactor-binding site [353-353]
FOR-BINDING-OF: pyridoxal phosphate
Database Correlations
OMIM 603729
UniProt O95470
Pfam PF00282
ENZYME 4.1.2.27
References
UniProt :accession O95470