sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 (degenerative spermatocyte homolog 2, DEGS2)

Function: - bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase & a sphingolipid C4-hydroxylase - lipid biosynthesis, sphingolipid biosynthesis Structure: - belongs to the fatty acid desaturase family, DEGS subfamily Compartment: endoplasmic reticulum membrane Expression: - highly expressed in skin, intestine & kidney - up-regulated during keratinocyte differentiation - not expressed at day 0 or day 3 after differentiation, detected on day 6 & increases by day 9

General

membrane protein myristoylated protein oxidoreductase

Properties

SIZE: entity length = 323 aa MW = 37 kD COMPARTMENT: endoplasmic reticulum MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate transmembrane domain {45-65} transmembrane domain {68-88} C4-hydroxylase activity {95-99} transmembrane domain {210-231}

Database Correlations

UniProt Q6QHC5 PFAM correlations

References

UniProt :accession Q6QHC5