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sperm antigen with calponin homology & coiled-coil domains 1 (nuclear structure protein 5, NSP5, sperm antigen HCMOGT-1, SPECC1, NSP5)
Structure:
- belongs to the cytospin-A family
Compartment: nucleus
Alternative splicing: named isoforms=5
Expression:
- highly expressed in testis
- arely detectable in other tissues
Pathology:
- highly expressed in some cancer cell lines
- chromosomal translocation t(5;17)(q33;p11.2) involving SPECC1 with PDGFRB may be a cause of juvenile myelomonocytic leukemia
General
nuclear protein
testis-specific protein
Properties
SIZE: MW = 119 kD
entity length = 1068 aa
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {260-372}
MOTIF: serine residue (SEVERAL)
coiled coil {579-773}
calponin homology domain
NAME: calponin homology domain
SITE: 962-1064
Database Correlations
UniProt Q5M775
Pfam PF00307
References
- UniProt :accession Q5M775
- Atlas Genet. Cytogenet. Oncol. Haematol.
http://atlasgeneticsoncology.org/Genes/HCMOGT1ID174.html