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spermidine synthase; SPDSY; putrescine aminopropyltransferase (SRM, SPS1, SRML1)
Function:
- activity is regulated by availability of decarboxylated S-adenosylmethionine (putative)
- amine & polyamine biosynthesis
- spermidine biosynthesis
- spermidine from putrescine: step 1/1
S-adenosylmethioninamine + putrescine
S-methyl-5'-thioadenosine + spermidine
Structure:
- homodimer or homotetramer
- the N-terminus is blocked
- belongs to the spermidine/spermine synthase family
General
aminotransferase
synthase
Properties
SIZE: entity length = 302 aa
MW = 34 kD
MOTIF: binding site
SITE: 49-49
FOR-BINDING-OF: S-adenosylmethioninamine
binding site
SITE: 104-104
FOR-BINDING-OF: S-adenosylmethioninamine
binding site
SITE: 124-124
FOR-BINDING-OF: S-adenosylmethioninamine
active site
S-adenosylmethioninamine binding {155-156}
binding site
SITE: 173-173
FOR-BINDING-OF: S-adenosylmethioninamine
Putrescine binding {174-176}
binding site
SITE: 241-241
FOR-BINDING-OF: Putrescine
Database Correlations
OMIM 182891
UniProt P19623
Pfam PF01564
Entrez Gene 6723
KEGG correlations
ENZYME 2.5.1.16
References
UniProt :accession P19623