Speedy protein A (Speedy-1, Spy1, rapid inducer of G2/M progression in oocytes A, RINGO A, hSpy/Ringo A, SPDYA, SPDY1, SPY1)

Function: - regulates the G1/S phase transition of the cell cycle by binding & activating CDC2, CDK2 & CDKN1B/KIP1 - can activate CDK2 without promoting CDK2 phosphorylation - mediates cell survival during the DNA damage process through activation of CDK2 - interacts with CDC2, CDK2 & CDKN1B/KIP1 - found in a complex with both CDK2 & CDKN1B/KIP1 Structure: - belongs to the Speedy/Ringo family - C-terminus is required for CDK2-activation, but not CDK2-binding Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - highly expressed in testis - expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea & uterus - expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate & trachea - expression is cell cycle-dependent, being restricted to cells in G1/S phase

General

nuclear protein Speedy/RINGO family

Properties

SIZE: MW = 36 kD entity length = 313 aa COMPARTMENT: cell nucleus MOTIF: Speedy/Ringo box; required for CDK- binding {68-200}

References

UniProt :accession Q5MJ70