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trefoil factor 2; spasmolysin; spasmolytic polypeptide; SP (TFF2, SML1)
Function:
- inhibits gastrointestinal motility & gastric acid secretion
- could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains
Structure: contains 2 P-type (trefoil) domains
Compartment: secreted
Expression: stomach
General
cell adhesion protein
secreted protein
Properties
SIZE: entity length = 129 aa
MW = 14 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
P-type 1 {29-73}
MOTIF: cysteine residue {C29}
MODIFICATION: cysteine residue {C127}
cysteine residue {C31}
MODIFICATION: cysteine residue {C58}
cysteine residue {C42}
MODIFICATION: cysteine residue {C57}
cysteine residue {C52}
MODIFICATION: cysteine residue {C69}
cysteine residue {C57}
MODIFICATION: cysteine residue {C42}
cysteine residue {C58}
MODIFICATION: cysteine residue {C31}
cysteine residue {C69}
MODIFICATION: cysteine residue {C52}
P-type 2 {79-122}
MOTIF: cysteine residue {C81}
MODIFICATION: cysteine residue {C107}
cysteine residue {C91}
MODIFICATION: cysteine residue {C106}
cysteine residue {C101}
MODIFICATION: cysteine residue {C118}
cysteine residue {C106}
MODIFICATION: cysteine residue {C91}
cysteine residue {C107}
MODIFICATION: cysteine residue {C81}
cysteine residue {C118}
MODIFICATION: cysteine residue {C101}
cysteine residue {C127}
MODIFICATION: cysteine residue {C29}
Database Correlations
OMIM 182590
UniProt Q03403
Pfam PF00088
Entrez Gene 7032
Kegg hsa:7032
References
- UniProt :accession Q03403
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TFF2ID264.html