Search
Sp110 nuclear body protein; interferon-induced protein 41/75; speckled 110 kD; transcriptional coactivator Sp110 (SP110)
Function:
- transcription factor
- may be a nuclear hormone receptor coactivator
- enhances transcription of genes with retinoic acid response elements (RARE)
- phosphorylated (isoform 2)
- isoform 3 interacts with HCV core protein
Structure:
- contains 1 bromo domain
- contains 1 HSR domain
- contains 1 PHD-type Zn+2 finger
- contains 1 SAND domain
Compartment:
- nucleus, found in the nuclear body
Alternative splicing: named isoforms=6
Expression:
- expressed in peripheral blood leukocytes & spleen > thymus, prostate, testis, ovary, small intestine & colon > heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
- induced by IFNG/IFN-gamma & all-trans retinoic acid (ATRA)
Pathology:
- defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 689 aa
MW = 78 kD
COMPARTMENT: cell nucleus
MOTIF: HSR {1-108}
Ser phosphorylation site {S175}
Ser phosphorylation site {S177}
Ser phosphorylation site {S256}
nuclear translocation signal {281-294}
nuclear translocation signal {428-444}
SAND {454-535}
MOTIF: domain {525-529}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 534-580
EFFECTOR-BOUND: Zn+2
bromodomain {581-676}
Database Correlations
OMIM correlations
MORBIDMAP 604457
UniProt Q9HB58
PFAM correlations
Entrez Gene 3431
Kegg hsa:3431
References
- UniProt :accession Q9HB58
- SP110base; Note: SP110 mutation db
http://bioinf.uta.fi/SP110base/
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/SP110