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SON protein; SON3; negative regulatory element-binding protein; NRE-binding protein; DBP-5; Bax antagonist selected in saccharomyces 1; BASS1 (SON C21orf50 DBP5 KIAA1019 NREBP)
Function:
- represses hepatitis B virus (HBV) core promoter activity & transcription of HBV genes & production of HBV virions
- binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'
- might protect cells from apoptosis
- might be involved in pre-mRNA splicing (putative)
Structure:
- contains 8 types of repeats which are distributed in 3 regions
- contains 1 DRBM domain (double-stranded RNA-binding)
- contains 1 G-patch domain
Compartment:
- nucleus speckle
- colocalizes with the pre-mRNA splicing factor SFRS2/SC-35
Alternative splicing: named isoforms=10
some isoform(s) may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- widely expressed, with the higher expression seen in leukocytes & heart
General
DNA-binding protein
phosphoprotein
Properties
SIZE: entity length = 2426 aa
MW = 264 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S94}
Ser phosphorylation site {S152}
Ser phosphorylation site {S154}
Ser phosphorylation site {S283}
Ser phosphorylation site {S348}
domain {726-895}
Ser phosphorylation site {S908}
Ser phosphorylation site {S910}
domain {912-988}
14 X 6 AA repeats of [ED]-R-S-M-M-S {1006-1126}
MOTIF: consensus repeat {1006-1011}
SEQUENCE-IS: 1-1
consensus repeat {1014-1019}
SEQUENCE-IS: 1-2
consensus repeat {1021-1026}
SEQUENCE-IS: 1-3
consensus repeat {1030-1035}
SEQUENCE-IS: 1-4
consensus repeat {1038-1043}
SEQUENCE-IS: 1-5
consensus repeat {1046-1051}
SEQUENCE-IS: 1-6
Ser phosphorylation site {S1051}
consensus repeat {1055-1060}
SEQUENCE-IS: 1-7
consensus repeat {1063-1068}
SEQUENCE-IS: 1-8
consensus repeat {1071-1076}
SEQUENCE-IS: 1-9
Ser phosphorylation site {S1076}
consensus repeat {1080-1085}
SEQUENCE-IS: 1-10
consensus repeat {1089-1094}
SEQUENCE-IS: 1-11
consensus repeat {1100-1105}
SEQUENCE-IS: 1-12
consensus repeat {1111-1116}
SEQUENCE-IS: 1-13
consensus repeat {1121-1126}
SEQUENCE-IS: 1-14
domain {1147-1179}
4 X 8 AA tandem repeats of V-L-E-SS- [AVT]-VT {1359-1390}
Ser phosphorylation site {S1556}
Ser phosphorylation site {S1651}
Ser phosphorylation site {S1688}
Ser phosphorylation site {S1697}
Ser phosphorylation site {S1766}
Ser phosphorylation site {S1769}
Ser phosphorylation site {S1782}
Ser phosphorylation site {S1783}
Ser phosphorylation site {S1784}
Ser phosphorylation site {S1820}
Ser phosphorylation site {S1821}
Ser phosphorylation site {S1824}
domain {1925-2013}
MOTIF: consensus repeat {1925-1931}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
consensus repeat {1934-1952}
SEQUENCE-IS: P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S
Ser phosphorylation site {S1948}
Ser phosphorylation site {S1950}
consensus repeat {1953-1959}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
Ser phosphorylation site {S1954}
consensus repeat {1960-1966}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
Ser phosphorylation site {S1961}
consensus repeat {1967-1973}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
consensus repeat {1974-1980}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
consensus repeat {1981-1987}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
consensus repeat {1988-1994}
SEQUENCE-IS: P-S-R-R-S-R-[TS]
consensus repeat {1995-2013}
SEQUENCE-IS: P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S
Ser phosphorylation site {S2009}
Ser phosphorylation site {S2011}
domain {2013-2039}
MOTIF: Ser phosphorylation site {S2013}
Ser phosphorylation site {S2029}
Ser phosphorylation site {S2031}
Ser phosphorylation site {S2129}
Thr phosphorylation site {T2163}
G-patch domain {2305-2351}
DRBM {2371-2426}
Database Correlations
OMIM 182465
UniProt P18583
PFAM correlations
Entrez Gene 6651
Kegg hsa:6651
References
UniProt :accession P18583