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some large E3 complex
Structure:
- consists of: UBE2D1, SIAH1, CACYBP, SKP1A, APC, TBL1X
General
ligase or synthetase
molecular complex
Properties
MOTIF: active site
SUBUNITS: ubiquitin-conjugating enzyme E2 D1
COMPARTMENT: cytoplasm
MOTIF: active site
MOTIF: cysteine residue
cysteine residue {C85}
E3 ubiquitin-protein ligase SIAH1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RING-finger {41-76}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
SBD {90-282}
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 93-153
EFFECTOR-BOUND: Zn+2
Zn+2-binding site
SITE: 98-98
Zn+2-binding site
SITE: 105-105
Zn+2-binding site
SITE: 117-117
Zn+2-binding site
SITE: 121-121
Zn+2-binding site
SITE: 128-128
Zn+2-binding site
SITE: 135-135
Zn+2-binding site
SITE: 147-147
Zn+2-binding site
SITE: 152-152
calcyclin-binding protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 1-80
FOR-BINDING-OF: E3 ubiquitin-protein ligase SIAH1
CS {73-167}
binding site
SITE: 73-228
FOR-BINDING-OF: S-phase kinase-associated protein 1
MOTIF: binding site
SITE: 154-228
FOR-BINDING-OF: protein S100-A6
SGS {168-228}
S-phase kinase-associated protein 1
MOTIF: F-box interaction {104-163}
F-box-like/WD repeat-containing protein TBL1X
COMPARTMENT: cell nucleus
MOTIF: LisH {55-87}
F-box domain {92-137}
alanine-rich region {159-175}
MOTIF: alanine residue (SEVERAL)
WD repeat {230-269}
WD repeat {286-325}
WD repeat {327-366}
WD repeat {369-409}
WD repeat {410-449}
WD repeat {452-500}
WD repeat {503-542}
WD repeat {544-576}
References
UniProt :accession Q9HB71
Components
calcyclin-binding protein (CacyBP, hCacyBP, Siah-interacting protein, S100A6-binding protein, CACYBP, S100A6BP, SIP, PNAS-107)
E3 ubiquitin-protein ligase SIAH1; seven in absentia homolog 1; siah-1; siah-1a (SIAH1 HUMSIAH)
F-box-like/WD repeat-containing protein TBL1X; SMAP55; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked (TBL1X TBL1)
S-phase kinase-associated protein 1; cyclin-A/CDK2-associated protein p19; p19skp1; p19A; RNA polymerase II elongation factor-like protein; organ of corti protein 2; OCP-2; organ of corti protein II; OCP-II; transcription elongation factor B; SIII (SKP1, EMC19, OCP2, SKP1A, TCEB1L)
ubiquitin-conjugating enzyme E2 D1; stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kD 1; ubiquitin-protein ligase D1 (UBE2D1 SFT UBC5A UBCH5 UBCH5A)