something about silencing protein 10; disrupter of silencing SAS10; charged amino acid-rich leucine zipper 1 (CRLZ1, SAS10, UTP3)

Function: - essential for gene silencing - role in structure of silenced chromatin - role in developing brain - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the SAS10 family Compartment: nucleus

General

phosphoprotein transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 55 kD entity length = 479 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S37} glutamate-rich region {72-164} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S150} Ser phosphorylation site {S365} Ser phosphorylation site {S368}

Database Correlations

UniProt Q9NQZ2 Pfam PF04000

References

UniProt :accession Q9NQZ2