somatostatin receptor 5; SS5R (SSTR5)

Function: - receptor for somatostatin-28 & to a lesser extent for somatostatin-14. - activity is mediated by G proteins which inhibit adenylyl cyclase Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - adult pituitary gland, heart, small intestine, adrenal gland, cerebellum - expressed in fetal hypothalamus - no expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary

General

glycoprotein phosphoprotein somatostatin receptor

Properties

SIZE: entity length = 364 aa MW = 39 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-38} MOTIF: N-glycosylation site {N13} N-glycosylation site {N26} transmembrane domain {39-66} cytoplasmic loop {67-76} transmembrane domain {77-101} exoplasmic loop {102-113} MOTIF: cysteine residue {C112} MODIFICATION: cysteine residue {C186} transmembrane domain {114-135} cytoplasmic loop {136-157} transmembrane domain {158-178} exoplasmic loop {179-197} MOTIF: cysteine residue {C186} MODIFICATION: cysteine residue {C112} N-glycosylation site {N187} transmembrane domain {198-222} cytoplasmic loop {223-247} transmembrane domain {248-273} exoplasmic loop {274-283} transmembrane domain {284-308} cytoplasmic domain {309-364} MOTIF: cysteine residue {C320} MODIFICATION: palmitate COMPARTMENT: membrane Ser phosphorylation site {S325}

Database Correlations

OMIM 182455 UniProt P35346 Pfam PF00001 Entrez Gene 6755 Kegg hsa:6755

References

UniProt :accession P35346