somatostatin receptor 4; SS4R; brain-specific somatostatin receptor (SSTR4)

Function: - receptor for somatostatin-14 - activity mediated by G proteins which inhibit adenylyl cyclase - functionally coupled to a) inhibition of adenylate cyclase b) activation of arachidonate release & mitogen-activated protein (MAP) kinase cascade - mediates antiproliferative action of somatostatin in tumor cells Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - specifically expressed in fetal & adult brain, lung tissue, stomach - lesser expression in kidney, pituitary & adrenals

General

glycoprotein somatostatin receptor

Properties

SIZE: entity length = 388 aa MW = 42 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-46} MOTIF: N-glycosylation site {N24} transmembrane domain {47-73} cytoplasmic loop {74-83} transmembrane domain {84-104} exoplasmic loop {105-120} MOTIF: cysteine residue {C119} MODIFICATION: cysteine residue {C198} transmembrane domain {121-142} cytoplasmic loop {143-161} transmembrane domain {162-185} exoplasmic loop {186-208} MOTIF: cysteine residue {C198} MODIFICATION: cysteine residue {C119} transmembrane domain {209-232} cytoplasmic loop {233-260} transmembrane domain {261-280} exoplasmic loop {281-291} transmembrane domain {292-314} cytoplasmic domain {315-388} MOTIF: cysteine residue {C327} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 182454 UniProt P31391 Pfam PF00001 Entrez Gene 6754

References

UniProt :accession P31391