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somatostatin receptor 3; SS3R; SSR-28 (SSTR3)
Function:
- receptor for somatostatin-14 & somatostatin-28
- coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
- phosphorylation increases upon somatostatin binding (putative)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane
- internalized into endoplasmic vesicles upon somatostatin- stimulation (putative)
Expression: brain, pituitary & pancreas
General
glycoprotein
phosphoprotein
somatostatin receptor
Properties
SIZE: entity length = 418 aa
MW = 46 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-43}
MOTIF: N-glycosylation site {N17}
N-glycosylation site {N30}
transmembrane domain {44-69}
cytoplasmic loop {70-79}
transmembrane domain {80-101}
exoplasmic loop {102-116}
MOTIF: cysteine residue {C116}
MODIFICATION: cysteine residue {C191}
transmembrane domain {117-138}
cytoplasmic loop {139-161}
transmembrane domain {162-181}
exoplasmic loop {182-205}
MOTIF: cysteine residue {C191}
MODIFICATION: cysteine residue {C116}
transmembrane domain {206-231}
cytoplasmic loop {232-257}
transmembrane domain {258-279}
exoplasmic loop {280-293}
transmembrane domain {294-316}
cytoplasmic domain {317-418}
MOTIF: Ser phosphorylation site {S332}
Ser phosphorylation site {S337}
glutamate-rich region {346-360}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T348}
Database Correlations
OMIM 182453
UniProt P32745
Pfam PF00001
Entrez Gene 6753
Kegg hsa:6753
References
UniProt :accession P32745