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somatostatin receptor 1; SS1R; SRIF-2 (SSTR1)
Function:
- receptor for somatostatin
- higher affinity for somatostatin-14 than somatostatin-28
- coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
- additionally, stimulates phosphotyrosine phosphatase & Na+/H+ exchanger via pertussis toxin insensitive G proteins
- interacts with SKB1
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- fetal kidney, fetal liver
- adult pancreas, brain, lung, jejunum & stomach
General
glycoprotein
somatostatin receptor
Properties
SIZE: entity length = 391 aa
MW = 43 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-56}
MOTIF: N-glycosylation site {N4}
N-glycosylation site {N44}
N-glycosylation site {N48}
transmembrane domain {57-84}
cytoplasmic loop {85-94}
transmembrane domain {95-120}
exoplasmic loop {121-131}
MOTIF: cysteine residue {C130}
MODIFICATION: cysteine residue {C208}
transmembrane domain {132-153}
cytoplasmic loop {154-175}
transmembrane domain {176-196}
exoplasmic loop {197-219}
MOTIF: cysteine residue {C208}
MODIFICATION: cysteine residue {C130}
transmembrane domain {220-244}
cytoplasmic loop {245-270}
transmembrane domain {271-296}
exoplasmic loop {297-303}
transmembrane domain {304-327}
cytoplasmic domain {328-391}
MOTIF: cysteine residue {C339}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 182451
UniProt P30872
Pfam PF00001
Entrez Gene 6751
Kegg hsa:6751
References
UniProt :accession P30872