Search
solute carrier family 8 member 3 (SLC8A3, Na+/Ca+2 exchanger 3, NCX3)
Function:
- rapid transport of Ca+2 during excitation-contraction coupling
- Ca+2 is extruded from the cell during relaxation so as to prevent Ca+2 overloading of intracellular stores (putative)
Structure:
- belongs to the Na+/K+/Ca+2 exchanger family, SLC8 subfamily
- contains 2 calx-beta domains
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- isoform 2: brain & skeletal muscle
- isoform 3: excitable cells of brain, retina & skeletal muscle
- isoform 4; skeletal muscle
General
glycoprotein
solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
transmembrane 11e protein
Properties
SIZE: MW = 103 kD
entity length = 927 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-73}
MOTIF: signal sequence {1-30}
N-glycosylation site {N45}
transmembrane domain {74-94}
cytoplasmic loop {95-147}
transmembrane domain {148-168}
exoplasmic loop {169-169}
transmembrane domain {170-190}
cytoplasmic loop {191-202}
transmembrane domain {203-223}
exoplasmic loop {224-230}
transmembrane domain {231-251}
cytoplasmic loop {252-726}
MOTIF: binding site
SITE: 253-272
FOR-BINDING-OF: calmodulin
transmembrane domain {727-747}
exoplasmic loop {748-754}
transmembrane domain {755-775}
cytoplasmic loop {776-778}
transmembrane domain {779-799}
exoplasmic loop {800-828}
MOTIF: N-glycosylation site {N823}
transmembrane domain {829-849}
cytoplasmic loop {850-860}
transmembrane domain {861-881}
exoplasmic loop {882-903}
transmembrane domain {904-924}
cytoplasmic domain {925-927}
Database Correlations
OMIM 607991
UniProt P57103
PFAM correlations
Kegg hsa:6547
References
UniProt :accession P57103