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solute carrier family 8 member 2; Na+/Ca+2 exchanger 2; Na+/Ca+2-exchange protein 2 (SLC8A2, KIAA1087, NCX2)
Function:
- rapidly transports Ca+2 during excitation-contraction coupling
- Ca+2 is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (putative)
Structure:
- belongs to the Na+/K+/Ca+2 exchanger family, SLC8 subfamily
- contains 2 calx-beta domains
Compartment: membrane
General
Ca+2 binding protein
glycoprotein
solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
transmembrane 11e protein
Properties
SIZE: entity length = 921 aa
MW = 100 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {21-68}
MOTIF: signal sequence {1-20}
proline-rich region
SITE: 29-32
MOTIF: proline residue (SEVERAL)
N-glycosylation site {N34}
transmembrane domain {69-90}
cytoplasmic loop {91-130}
transmembrane domain {131-152}
Alpha-1 {135-175}
MOTIF: exoplasmic loop {153-164}
transmembrane domain {165-185}
cytoplasmic loop {186-196}
transmembrane domain {197-219}
exoplasmic loop {220-222}
transmembrane domain {223-246}
cytoplasmic loop {247-720}
MOTIF: calmodulin binding site
SITE: 248-267
FOR-BINDING-OF: calmodulin
Calx-beta 1 {384-483}
Calx-beta 2 {512-612}
glutamate-rich region {638-641}
MOTIF: glutamate residue (SEVERAL)
transmembrane domain {721-740}
exoplasmic loop {741-747}
transmembrane domain {748-770}
cytoplasmic loop {771-772}
transmembrane domain {773-791}
Alpha-2 {790-826}
MOTIF: exoplasmic loop {792-822}
N-glycosylation site {N817}
transmembrane domain {823-843}
cytoplasmic loop {844-854}
transmembrane domain {855-875}
exoplasmic loop {876-892}
transmembrane domain {893-909}
cytoplasmic domain {910-921}
Database Correlations
OMIM 601901
UniProt Q9UPR5
PFAM correlations
Entrez Gene 6543
Kegg hsa:6543
References
UniProt :accession Q9UPR5