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solute carrier family 8 member 1; Na+/Ca+2 exchanger 1; Na+/Ca+2-exchange protein 1 (SLC8A1, CNC, NCX1)
Function:
- rapidly transports Ca+2 during excitation-contraction coupling
- Ca+2 is extruded from the cell during relaxation so as to prevent overloading of intracellular stores by ATP
Structure:
- belongs to the Na+/K+/Ca+2 exchanger family, SLC8 subfamily
- contains 2 calx-beta domains
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=4
Expression:
- expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta & lung
General
Ca+2 binding protein
glycoprotein
phosphoprotein
solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
transmembrane 11e protein
Properties
SIZE: entity length = 973 aa
MW = 109 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {36-74}
MOTIF: signal sequence {1-35}
N-glycosylation site {N44}
transmembrane domain {75-96}
cytoplasmic loop {97-136}
transmembrane domain {137-158}
exoplasmic loop {159-170}
MOTIF: N-glycosylation site {N160}
transmembrane domain {171-191}
cytoplasmic loop {192-202}
transmembrane domain {203-225}
exoplasmic loop {226-228}
transmembrane domain {229-252}
cytoplasmic loop {253-772}
MOTIF: calmodulin binding site
SITE: 254-273
FOR-BINDING-OF: calmodulin
Ser phosphorylation site {S392}
Calx-beta 1 {396-496}
Calx-beta 2 {527-627}
glutamate-rich region {692-695}
MOTIF: glutamate residue (SEVERAL)
transmembrane domain {773-792}
exoplasmic loop {793-799}
transmembrane domain {800-822}
cytoplasmic loop {823-824}
transmembrane domain {825-843}
exoplasmic loop {844-874}
MOTIF: N-glycosylation site {N869}
transmembrane domain {875-895}
cytoplasmic loop {896-906}
transmembrane domain {907-927}
exoplasmic loop {928-944}
transmembrane domain {945-961}
cytoplasmic domain {962-973}
Database Correlations
OMIM 182305
UniProt P32418
PFAM correlations
Entrez Gene 6546
Kegg hsa:6546
References
UniProt :accession P32418