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solute carrier family 7 member 11; cystine/glutamate transporter; amino acid transport system xc-; Ca+2 channel blocker resistance protein CCBR1; xCT (SLC7A11)
Function:
- Na+-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine & glutamate
- disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (putative)
Structure:
- belongs to the amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Compartment: membrane
General
glycoprotein
phosphoprotein
solute carrier family 7 (SLC7, SLC7A)
transmembrane 12 protein
Properties
SIZE: entity length = 501 aa
MW = 55 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-43}
MOTIF: Ser phosphorylation site {S26}
transmembrane domain {44-64}
exoplasmic loop {65-74}
transmembrane domain {75-95}
cytoplasmic loop {96-113}
transmembrane domain {114-134}
exoplasmic loop {135-158}
transmembrane domain {159-179}
cytoplasmic loop {180-189}
transmembrane domain {190-210}
exoplasmic loop {211-234}
transmembrane domain {235-255}
cytoplasmic loop {256-265}
transmembrane domain {266-286}
exoplasmic loop {287-317}
MOTIF: N-glycosylation site {N314}
transmembrane domain {318-338}
cytoplasmic loop {339-364}
transmembrane domain {365-385}
exoplasmic loop {386-387}
transmembrane domain {388-408}
cytoplasmic loop {409-422}
transmembrane domain {423-443}
exoplasmic loop {444-449}
transmembrane domain {450-470}
cytoplasmic domain {471-501}
Database Correlations
OMIM 607933
UniProt Q9UPY5
Pfam PF00324
Entrez Gene 23657
Kegg hsa:23657
References
UniProt :accession Q9UPY5