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solute carrier family 6 member 5; Na+- & chloride-dependent glycine transporter 2; GlyT-2; GlyT2 (SLC6A5, GLYT2, NET1)
Function:
- terminates the action of glycine by its high affinity Na+-dependent reuptake into presynaptic terminals
- may be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses
Structure:
- belongs to the Na+:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A5 subfamily
Compartment: membrane
Expression:
- expressed in medulla oblongata, & to a lesser extent in spinal cord & cerebellum
Pathology:
- defects in SLC6A5 are a cause of startle disease
General
glycoprotein
solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)
Properties
SIZE: entity length = 797 aa
MW = 87 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-199}
transmembrane domain {200-220}
exoplasmic loop {221-227}
transmembrane domain {228-247}
cytoplasmic loop {248-270}
transmembrane domain {271-291}
exoplasmic loop {292-393}
MOTIF: N-glycosylation site {N343}
N-glycosylation site {N353}
N-glycosylation site {N358}
N-glycosylation site {N364}
transmembrane domain {394-412}
cytoplasmic loop {413-420}
transmembrane domain {421-438}
exoplasmic loop {439-473}
transmembrane domain {474-491}
cytoplasmic loop {492-502}
transmembrane domain {503-524}
exoplasmic loop {525-556}
transmembrane domain {557-576}
cytoplasmic loop {577-603}
transmembrane domain {604-622}
exoplasmic loop {623-637}
transmembrane domain {638-658}
cytoplasmic loop {659-678}
transmembrane domain {679-698}
exoplasmic loop {699-716}
transmembrane domain {717-735}
cytoplasmic domain {736-797}
Database Correlations
OMIM correlations
MORBIDMAP 604159
UniProt Q9Y345
Pfam PF00209
Entrez Gene 9152
Kegg hsa:9152
References
UniProt :accession Q9Y345