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solute carrier family 6 member 12; Na+/Cl- betaine/GABA transporter; BGT-1 (SLC6A12)
Function:
- transports betaine & GABA
- role in regulation of GABAergic transmission in brain via:
a) reuptake of GABA into presynaptic terminals
b) osmotic regulation
- interacts with LIN7C (putative)
Structure:
- belongs to the Na+:neurotransmitter symporter (SNF) family
Compartment: membrane
Expression:
- liver, heart, skeletal muscle, placenta
- widespread distribution in brain
General
glycoprotein
solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)
Properties
SIZE: MW = 69 kD
entity length = 614 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-44}
transmembrane domain {45-65}
exoplasmic loop {66-72}
transmembrane domain {73-92}
cytoplasmic loop {93-116}
transmembrane domain {117-137}
exoplasmic loop {138-210}
MOTIF: N-glycosylation site {N171}
N-glycosylation site {N183}
transmembrane domain {211-229}
cytoplasmic loop {230-237}
transmembrane domain {238-255}
exoplasmic loop {256-290}
transmembrane domain {291-308}
cytoplasmic loop {309-319}
transmembrane domain {320-341}
exoplasmic loop {342-373}
transmembrane domain {374-393}
cytoplasmic loop {394-422}
transmembrane domain {423-441}
exoplasmic loop {442-457}
transmembrane domain {458-478}
cytoplasmic loop {479-498}
transmembrane domain {499-518}
exoplasmic loop {519-537}
transmembrane domain {538-556}
cytoplasmic domain {557-614}
Database Correlations
OMIM 603080
UniProt P48065
Pfam PF00209
References
UniProt :accession P48065